The transient receptor potential vanilloid 1 (TRPV1) receptor may be involved in this syndrome. N2 - Background: Cannabinoid hyperemesis syndrome (CHS) is characterized by symptoms of cyclic abdominal pain, nausea, and vomiting in the setting of prolonged cannabis use. © 2017 Informa UK Limited, trading as Taylor & Francis Group. T1 - Resolution of cannabis hyperemesis syndrome with topical capsaicin in the emergency department Conclusion: Topical capsaicin was associated with improvement in symptoms of CHS after other treatments failed.", Results: All 13 patients experienced symptom relief after administration of capsaicin cream. Methods: A query of the electronic health record at both centers identified thirteen patients with documented daily cannabis use and symptoms consistent with CHS who were administered topical capsaicin cream for symptom management. Purpose: We describe a series of thirteen cases of suspected cannabis hyperemesis syndrome treated with capsaicin in the emergency departments of two academic medical centers. This may explain its apparent antiemetic effect in this syndrome. Topical capsaicin is a proposed treatment for CHS it binds TRPV1 with high specificity, impairing substance P signaling in the area postrema and nucleus tractus solitarius via overstimulation of TRPV1. Conclusion: Topical capsaicin was associated with improvement in symptoms of CHS after other treatments failed.Ībstract = "Background: Cannabinoid hyperemesis syndrome (CHS) is characterized by symptoms of cyclic abdominal pain, nausea, and vomiting in the setting of prolonged cannabis use. Background: Cannabinoid hyperemesis syndrome (CHS) is characterized by symptoms of cyclic abdominal pain, nausea, and vomiting in the setting of prolonged cannabis use.
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